General Cell Based Assays
Eurofins Discoverx PathHunter MC4R Bioassay Kit, 2-Plate. (93-0211Y3-00085)
The PathHunter MC4R Bioassay kit provides an easy-to-use cell based assay to measure drug potency and detect neutralizing antibodies. This bioassay assesses ligand (e.g. αMSH) based activation of MC4R GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged MC4R and EA-tagged β-Arrestin-2. Activation of MC4R stimulates the recruitment of β-Arrestin-2 and produces EFC signal. Bioassay kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, control agonist, detection reagent, and assay plates. For detailed product information, User manual and COA, visit www.discoverx.com/bioassay.
Eurofins Discoverx PathHunter eXpress EDG1 CHO-K1 β-Arrestin GPCR Assay, 10-Plate Kit. (93-0207E2CP4L)
The PathHunter EDG1 eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. S1P) based activation of EDG1 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged EDG1 and EA-tagged β-Arrestin-2. Activation of EDG1 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx AssayComplete Cell Culture Kit-105, (92-3105G)
AssayComplete Cell Culture Kit-105 is an optimized media kit intended for use in culturing and propagating Eurofins DiscoverX cell lines. This kit contains the base medium, relevant serum, and pen/strep required to produce a full cell culture medium for optimal cell culture results. This product is provided as a 3-component kit which will produce approximately 550 mL of finished media. Please refer to cell line specific datasheet to determine the recommended cell culture kit. For detailed product information, User manual and datasheet, visit www.discoverx.com/reagents.
Sigma Aldrich Fine Chemicals Biosciences Pyruvate Kinase/Lactic Deh
Pyruvate Kinase from rabbit muscle is a metalloenzyme which catalyzes the conversion of phosphoenol pyruvate to pyruvate in the glycolysis pathway. It corresponds to a molecular weight of 59 kDa. It exists as a tetramer and undergoes conformational changes in the active site to accommodate substrate. Lactic dehydrogenase (LDH) catalyzes the lactate to pyruvate conversion in anaerobic glycolysis. It exists as tetramer and comprises of two subunits (H and M). The LDH of eukaryotes undergo active-site loop gating for their catalytic functionality.
Sigma Aldrich Fine Chemicals Biosciences L Lactate Assay Kit suffic
Lactate is generated by lactate dehydrogenase (LDH) under hypoxic or anaerobic conditions. Monitoring lactate levels is therefore a good indicator of the balance between tissue oxygen demand and utilization and is useful when studying cellular and animal physiology. Simple direct and automation-ready procedures for measuring lactate concentration are very desirable.
Sigma Aldrich Fine Chemicals Biosciences Pyruvate Assay Kit suffici
Pyruvate is a key intermediate in cellular metabolic pathways. Pyruvate can be converted to carbohydrates via gluconeogenesis to fatty acids or energy through acetyl-CoA to the amino acid alanine and to ethanol. Abnormal levels of pyruvate have been linked to liver diseases and metabolic disorders. Simple direct and automation-ready procedures for measuring pyruvate concentrations find wide applications in research and drug discovery.
Sigma Aldrich Fine Chemicals Biosciences D Lactate Assay Kit suffic
Lactate is generated by lactate dehydrogenase (LDH) under hypoxic or anaerobic conditions. Monitoring lactate levels is therefore a good indicator of the balance between tissue oxygen demand and utilization and is useful when studying cellular and animal physiology. D-lactate is produced in only minor quantities in animals and measuring for D-lactate in animal samples is a means to determine the presence of bacterial infection. Simple direct and automation-ready procedures for measuring lactate concentration are very desirable.
Eurofins Discoverx PathHunter eXpress PTGER2 CHO-K1 β-Arrestin GPCR Assay, 10-Plate Kit. (93-0214E2CP2L)
The PathHunter PTGER2 eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. prostaglandin E2) based activation of PTGER2 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged PTGER2 and EA-tagged β-Arrestin-2. Activation of PTGER2 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress CRHR1 CHO-K1 β-Arrestin GPCR Assay, 10-Plate Kit. (93-0225E2CP0L)
The PathHunter CRHR1 eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. CRH, sauvagine) based activation of CRHR1 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged CRHR1 and EA-tagged β-Arrestin-2. Activation of CRHR1 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Cayman Chemical 33-BCRP InhIbItr 10mg
A BCRP inhibitor; sensitizes mitoxantrone-resistant H460/MX20 cells to mitoxantrone-induced cell death alone and in combination with UV radiation; sensitizes KB-C2 cells overexpressing P-gp to colchicine-induced cell death; increases intracellular accumulation of mitoxantrone in H460/MX20 cells at 5 µM
Genscript Corporation Trastuzumab Immunogenicity Kit
GenScript Trastuzumab Immunogenicity Kit (Bridging ELISA) is designed for detection of anti-Trastuzumab antibody in serum and plasma samples This kit utilizes a validated bridgingimmunoassay method based on the FDA EMA and NMPA Immunogenicity Guidelines Through rigorous validation studies the kit has been demonstrated high sensitivity specificity and is free from matrix effects It is an ideal tool for the analysis of ADA against Trastuzumab
American Research Products Inc THIOREDOXIN REDUCTASE TRXR KIT
5000265405 THIOREDOXIN REDUCTASE TRXR KIT
American Research Products Inc ACETALDEHYDE COLORIMETRIC KIT
5000265379 ACETALDEHYDE COLORIMETRIC KIT
American Research Products Inc KINASE KIT FLUOROMETRIC BA0125
5000265422 KINASE KIT FLUOROMETRIC BA0125
American Research Products Inc CALCIUM KIT COLORIMETRIC BA003
5000265297 CALCIUM KIT COLORIMETRIC BA003